{"id":73491,"date":"2026-10-23T08:08:15","date_gmt":"2026-10-23T12:08:15","guid":{"rendered":"https:\/\/www2.stockmarketwatch.com\/stock-market-news\/ukraine-and-russia-execute-major-270-person-prisoner-swap-bristol-myers-reports-breakthrough-breast-cancer-data\/73491\/"},"modified":"2026-10-23T08:08:15","modified_gmt":"2026-10-23T12:08:15","slug":"ukraine-and-russia-execute-major-270-person-prisoner-swap-bristol-myers-reports-breakthrough-breast-cancer-data","status":"publish","type":"post","link":"https:\/\/www2.stockmarketwatch.com\/stock-market-news\/ukraine-and-russia-execute-major-270-person-prisoner-swap-bristol-myers-reports-breakthrough-breast-cancer-data\/73491\/","title":{"rendered":"Ukraine and Russia Execute Major 270-Person Prisoner Swap; Bristol-Myers Reports Breakthrough Breast Cancer Data"},"content":{"rendered":"<h2>Key Takeaways<\/h2>\n<ul>\n<li><strong>Bristol-Myers Squibb (<a href=\"\/stock\/BMY\">BMY<\/a>)<\/strong> announced that its investigational drug <strong>iza-bren<\/strong> reduced the risk of disease progression or death by <strong>59%<\/strong> in a Phase 3 breast cancer study, significantly outperforming standard chemotherapy.<\/li>\n<li>Ukraine and Russia completed a major prisoner exchange involving <strong>540 total servicemen<\/strong>, with each side returning <strong>270 people<\/strong> following successful negotiations.<\/li>\n<li>The <strong>iza-bren<\/strong> clinical results showed a median progression-free survival (PFS) of <strong>8.2 months<\/strong> compared to <strong>4.0 months<\/strong> for the chemotherapy control group.<\/li>\n<li>Ukrainian President <strong>Volodymyr Zelenskyy<\/strong> confirmed the return of 270 Ukrainians, many of whom were defenders of <strong>Mariupol<\/strong> and had been in captivity since 2022.<\/li>\n<li><strong>BMY<\/strong> shares rose over <strong>3%<\/strong> in early trading as investors reacted to the late-breaking data presented at the <strong>ESMO 2026 Congress<\/strong>.<\/li>\n<\/ul>\n<h2>Bristol-Myers Squibb Unveils Superior Phase 3 Breast Cancer Results<\/h2>\n<p><strong>Bristol-Myers Squibb (<a href=\"\/stock\/BMY\">BMY<\/a>)<\/strong> and partner <strong>SystImmune<\/strong> reported groundbreaking results from the Phase 3 <strong>PANKU-Breast01<\/strong> trial at the European Society for Medical Oncology (ESMO) 2026 Congress. The study evaluated <strong>izalontamab brengitecan (iza-bren)<\/strong>, a first-in-class dual-targeting bispecific antibody-drug conjugate (ADC), in patients with advanced <strong>HR+\/HER2- breast cancer<\/strong>.<\/p>\n<p>The trial met its primary endpoint with a <strong>59% reduction<\/strong> in the risk of disease progression or death. The confirmed objective response rate (cORR) for patients receiving <strong>iza-bren<\/strong> was <strong>40.5%<\/strong>, doubling the <strong>20.2%<\/strong> response rate observed in the chemotherapy arm. Additionally, the median duration of response (mDOR) was extended to <strong>6.9 months<\/strong> from the <strong>4.2 months<\/strong> seen with standard care.<\/p>\n<p>Market analysts noted that the safety profile remained manageable, with only <strong>1.6%<\/strong> of patients discontinuing treatment due to adverse events. These results position <strong>iza-bren<\/strong> as a potential new standard of care for patients who have failed prior lines of endocrine therapy and chemotherapy.<\/p>\n<h2>Ukraine and Russia Conduct Large-Scale Prisoner Exchange<\/h2>\n<p>In a significant humanitarian development, Ukraine and Russia exchanged <strong>270 prisoners of war each<\/strong> on Friday, October 23. President <strong>Volodymyr Zelenskyy<\/strong> announced the successful return of Ukrainian service members, including personnel from the <strong>National Guard<\/strong>, <strong>Azov unit<\/strong>, and <strong>Border Guards<\/strong>.<\/p>\n<p>The swap, mediated through ongoing diplomatic channels, also saw the return of <strong>nine Ukrainian civilians<\/strong>. Notably, five of the returned individuals were previously believed to have died during the 2022 attack on the <strong>Olenivka prison<\/strong>. This exchange marks the <strong>11th reported swap of 2026<\/strong>, highlighting a rare but consistent area of cooperation between the two warring nations.<\/p>\n<p>The Russian Defense Ministry confirmed that its <strong>270 returned servicemen<\/strong> were transported to Belarus for medical and psychological rehabilitation. While broader peace negotiations remain stalled, officials from both sides indicated that further exchanges of civilians and military personnel are expected to continue in the coming days.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Key Takeaways Bristol-Myers Squibb (BMY) announced that its investigational drug iza-bren reduced the risk of disease progression or death by 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